منابع مشابه
Transcription factor translated in axons
F ilters in the mammalian kidney must be unclogged by a transport receptor, say Shreeram Akilesh, Andrey Shaw (Washington University, St. Louis, MO), and colleagues. The receptor moves obstructing proteins into the urine, where they can later be returned to the bloodstream. The kidney fi lters the blood through a bed of capillaries known as the glomerulus. Large and highly charged proteins are ...
متن کاملStay-at-home transcription factor saves axons
T he old saw that local actions can have global consequences holds true for neurons, too. Selvaraj et al. show that a transcription factor remains in the axon to help prevent neurodegeneration (1). In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), neurons usually die in stages, with axons deteriorating fi rst and the cells themselves perishing later (2). Axon degenerati...
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ترجمه متون ادبی در دنیای امروز از اهمیت ویژه ای برخوردار است. فرهنگ های مختلف با استفاده از متون ادبی ملل و فرهنگ های دیگر سعی در غنی کردن فرهنگ و ادبیات کشور خود دارند. کشور ما نیز از این قاعده مستثنی نیست. در ایران، ترجمه متون ادبی اروپائی که با دوران مشروطه ایرانی آغاز می شود موجب تغییرات اساسی در فرهنگ، شیوه زندگی و تفکر ایرانیان شده است. در این دوران نه تنها در امورات سیاسی و فکری کشور تغی...
15 صفحه اولAxons regulate Schwann cell expression of the POU transcription factor SCIP.
SCIP (suppressed cAMP-inducible POU) is a POU domain transcription factor expressed by Schwann cells. Drugs that elevate intracellular cAMP, such as forskolin, increase the expression of SCIP and partially mimic the inductive effects of axons on Schwann cell gene expression. Thus, SCIP may be involved in a differentiation pathway in Schwann cells that is activated by axons. We have examined thi...
متن کاملWinged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus.
Our aim was to study the mechanisms of brain histogenesis. As a model, we have used the role of winged helix transcription factor gene Foxb1 in the emergence of a very specific morphological trait of the diencephalon, the mammillary axonal complex. Foxb1 is expressed in a large hypothalamic neuronal group (the mammillary body), which gives origin to a major axonal bundle with branches to thalam...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1803rr4